Shielding Effect of Ryanodine Receptor Modulator in Rat Model of Autism

Introduction: A neurodevelopmental disorder, autism is typically identified with three primary behavioral consequences, such as social impairment, communication problems, and limited or stereotypical behavior. Because of its co-morbidity lack therapeutic options, a global economic burden. short chain fatty acid, propionic acid formed biologically by the gut microbiome. Propionic levels that are too high can cause leaky intestines, which lead to autism-like symptoms. Methods: To induce autism, male Albino Wistar rats were given (250 mg/kg/po on 21st, 22nd, 23rd postnatal days). Rats also received ryanodine receptor antagonist (Ruthenium red: 3 mg/kg/po; 21st 50th day) see what influence it had acid-induced autism. Anxiety, behavior, repeated behaviors all assessed, well oxidative stress, inflammatory indicators, neuro signaling proteins, blood-brain barrier permeability. Results: Ruthenium red was found counter increases in anxiety, repetitive behavior prefrontal cortex IL-6, TNF-α, TBARS, Evans blue leakage, water content along decreases IL-10, GSH followed hippocampus CREB BDNF levels. Conclusion: Ryanodine antagonists presented neuroprotective effect conditions like modulatory effects neuroinflammation, neuroprotein changes. receptors be further explored depth manage condition.